AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissues

BACKGROUND: The Aurora family of serine-threonine kinases are essential regulators of cell division in mammalian cells. Aurora-A and –B expression and kinase activity is elevated in a variety of human cancers and is associated with high proliferation rates and poor prognosis. AMG 900 is a highly pot...

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Библиографические подробности
Опубликовано в: :J Transl Med
Главные авторы: Juan, Gloria, Bush, Tammy L, Ma, Connie, Manoukian, Raffi, Chung, Grace, Hawkins, Jennifer M, Zoog, Stephen, Kendall, Richard, Radinsky, Robert, Loberg, Robert, Friberg, Greg, Payton, Marc
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2014
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221688/
https://ncbi.nlm.nih.gov/pubmed/25367255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0307-x
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