Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice

Rapamycin, an allosteric inhibitor of the mTOR kinase, increases longevity in mice in a sex-specific manner. In contrast to the widely accepted theory that a loss of proteasome activity is detrimental to both life- and healthspan, biochemical studies in vitro reveal that rapamycin inhibits 20S prote...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Mol Neurosci
Egile Nagusiak: Rodriguez, Karl A., Dodds, Sherry G., Strong, Randy, Galvan, Veronica, Sharp, Z. D., Buffenstein, Rochelle
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2014
Gaiak:
Neuroscience
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220119/
https://ncbi.nlm.nih.gov/pubmed/25414638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00083
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