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Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice
Rapamycin, an allosteric inhibitor of the mTOR kinase, increases longevity in mice in a sex-specific manner. In contrast to the widely accepted theory that a loss of proteasome activity is detrimental to both life- and healthspan, biochemical studies in vitro reveal that rapamycin inhibits 20S prote...
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| Publicado no: | Front Mol Neurosci |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4220119/ https://ncbi.nlm.nih.gov/pubmed/25414638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00083 |
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