Function characterization of a glyco-engineered anti-EGFR monoclonal antibody cetuximab in vitro

AIM: To evaluate the biochemical features and activities of a glyco-engineered form of the anti-human epidermal growth factor receptor monoclonal antibody (EGFR mAb) cetuximab in vitro. METHODS: The genes encoding the Chinese hamster bisecting glycosylation enzyme (GnTIII) and anti-human EGFR mAb we...

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Publicado no:Acta Pharmacol Sin
Main Authors: Yi, Chang-hong, Ruan, Can-ping, Wang, Hao, Xu, Xin-yun, Zhao, Yun-peng, Fang, Meng, Ji, Jun, Gu, Xing, Gao, Chun-fang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220073/
https://ncbi.nlm.nih.gov/pubmed/25263334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.77
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