Deciphering clonality in aneuploid breast tumors using SNP array and sequencing data

Intra-tumor heterogeneity concerns the existence of genetically different subclones within the same tumor. Single sample quantification of heterogeneity relies on precise determination of chromosomal copy numbers throughout the genome, and an assessment of whether identified mutation variant allele...

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Veröffentlicht in:Genome Biol
Hauptverfasser: Lönnstedt, Ingrid M, Caramia, Franco, Li, Jason, Fumagalli, Debora, Salgado, Roberto, Rowan, Andrew, Salm, Max, Kanu, Nnennaya, Savas, Peter, Horswell, Stuart, Gade, Stephan, Loibl, Sibylle, Neven, Patrick, Sotiriou, Christos, Swanton, Charles, Loi, Sherene, Speed, Terence P
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220069/
https://ncbi.nlm.nih.gov/pubmed/25270265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0470-7
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