Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function

Iron excess is closely associated with tumorigenesis in multiple types of human cancers, with underlying mechanisms yet unclear. Recently, iron deprivation has emerged as a major strategy for chemotherapy, but it exerts tumor suppression only on select human malignancies. Here, we report that the tu...

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Vydáno v:Cell Rep
Hlavní autoři: Shen, Jia, Sheng, Xiangpeng, Chang, ZeNan, Wu, Qian, Wang, Sheng, Xuan, Zongliang, Li, Dan, Wu, Yalan, Shang, Yongjia, Kong, Xiangtao, Yu, Long, Li, Lin, Ruan, Kangchen, Hu, Hongyu, Huang, Ying, Hui, Lijian, Xie, Dong, Wang, Fudi, Hu, Ronggui
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219651/
https://ncbi.nlm.nih.gov/pubmed/24685134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.02.042
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