PM-02 DIACYLGLYCEROL KINASE ALPHA INHIBITION PROLONGS SURVIVAL OF MICE WITH PRIMARY AND METASTATIC BRAIN TUMORS

Diacylglycerol kinases (DGKs) are a family of highly conserved enzymes that are promiscuously responsive to growth factors and other mitogenic signaling cascades. DGKs are activated by binding of Ca2+ and phosphoserine, and catalyze conversion of diacylglycerol (DAG) to phosphatidic acid (PA). PA ha...

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Detalhes bibliográficos
Main Authors: Floyd, Desiree, Comeau, Laurey, Boroda, Salome, Hayes, Nik, Roller, Devin, Xiao, Aizhen, Friedman, Alina, Boyd, Louisa, Gioeli, Daniel, Harris, Tajie, Harris, Thurl, Purow, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218481/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou268.2
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