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Dual activities of ritanserin and R59022 as DGKα inhibitors and serotonin receptor antagonists
Diacylglycerol kinase alpha (DGKα) catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). Recently, DGKα was identified as a therapeutic target in various cancers, as well as in immunotherapy. Application of small-molecule DGK inhibitors, R59022 and R59949, induces cancer cell d...
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| Publicado no: | Biochem Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5164959/ https://ncbi.nlm.nih.gov/pubmed/27974147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.10.011 |
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