Loading...

Dual activities of ritanserin and R59022 as DGKα inhibitors and serotonin receptor antagonists

Diacylglycerol kinase alpha (DGKα) catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). Recently, DGKα was identified as a therapeutic target in various cancers, as well as in immunotherapy. Application of small-molecule DGK inhibitors, R59022 and R59949, induces cancer cell d...

Full description

Saved in:
Bibliographic Details
Published in:Biochem Pharmacol
Main Authors: Boroda, Salome, Niccum, Maria, Raje, Vidisha, Purow, Benjamin W., Harris, Thurl E.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5164959/
https://ncbi.nlm.nih.gov/pubmed/27974147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.10.011
Tags: Add Tag
No Tags, Be the first to tag this record!