GE-09 TERT PROMOTER MUTATION, IDH MUTATION AND 1p/19q CODELETION DEFINE FIVE GLIOMA MOLECULAR GROUPS WITH SPECIFIC CLINICAL CHARACTERISTICS AND GERMLINE VARIANT ASSOCIATIONS

Defining homogenous etiologic and clinical subgroups of infiltrative glioma by grade and histology has been challenging. We hypothesized that TERT promoter mutation, IDH mutation and 1p/19q codeletion in grade II-IV gliomas will generate clinically-homogeneous groups that are enriched for other acqu...

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Main Authors: Eckel-Passow, Jeanette, Lachance, Daniel, Walsh, Kyle, Decker, Paul, Sicotte, Hugues, Pekmezci, Melike, Molinaro, Annette, Rice, Terri, Kosel, Matt, Smirnov, Ivan, Sarkar, Gobinda, Caron, Alissa, Kollmeyer, Thomas, Giannini, Caterina, Huse, Jason, Tihan, Tarik, Wiemels, Joseph, Wiencke, John, Wrensch, Margaret, Jenkins, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218213/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou256.9
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