載入...
ET-08 DEMETHYLATING THERAPY INDUCES DIFFERENTATION AND THERAPEUTIC RESPONSE IN IDH1 MUTANT MALIGNANT GLIOMAS
Isocitrate Dehydrogenase 1 (IDH1) mutations are frequent in progressive GBMs and the grade II and III gliomas from which they arise. The mutant IDH1 enzyme pathologically produces 2-hydroxyglutarate (2-HG) that metabolically inhibits α-ketogluterate dependent histone and DNA demethylases. This resul...
Na minha lista:
| Main Authors: | , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2014
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4218171/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.8 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|