ET-08 DEMETHYLATING THERAPY INDUCES DIFFERENTATION AND THERAPEUTIC RESPONSE IN IDH1 MUTANT MALIGNANT GLIOMAS

Isocitrate Dehydrogenase 1 (IDH1) mutations are frequent in progressive GBMs and the grade II and III gliomas from which they arise. The mutant IDH1 enzyme pathologically produces 2-hydroxyglutarate (2-HG) that metabolically inhibits α-ketogluterate dependent histone and DNA demethylases. This resul...

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Main Authors: Borodovsky, Alexandra, Riggins, Gregory
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218171/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.8
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