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ET-08 DEMETHYLATING THERAPY INDUCES DIFFERENTATION AND THERAPEUTIC RESPONSE IN IDH1 MUTANT MALIGNANT GLIOMAS
Isocitrate Dehydrogenase 1 (IDH1) mutations are frequent in progressive GBMs and the grade II and III gliomas from which they arise. The mutant IDH1 enzyme pathologically produces 2-hydroxyglutarate (2-HG) that metabolically inhibits α-ketogluterate dependent histone and DNA demethylases. This resul...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4218171/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.8 |
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