ET-32 HYPOXIA REDUCTION IN INTRACRANIAL GLIOBLASTOMA MODELS BY OMX-4.80P, A PEGylated ENGINEERED H-NOX OXYGEN CARRIER THAT IS LONG-LASTING IN CIRCULATION AND SAFE

BACKGROUND: Hypoxic cells in solid tumors are resistant to radiotherapy. Omniox has developed a novel class of oxygen carrier proteins termed H-NOX, engineered to deliver oxygen selectively into hypoxic tissues. Previous studies have shown that one of our H-NOX candidates, OMX-4.80, penetrates intra...

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Hauptverfasser: Le Moan, Natacha, Getz, Jen, Ng, Sarah, Davis, Tina, Bedard, Catherine, Davis, Andrew, Leung, Philberta, Serwer, Laura, Tanaka, Kevin, Keating, Tim, Yan, Feng, Winger, Jonathan, Cary, Stephen, Krtolica, Ana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218129/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.32
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