AI-25 THE NOVEL c-MET INHIBITOR ALTIRATINIB (DCC-2701) INHIBITS TUMOR GROWTH AND INVASION IN A BEVACIZUMAB RESISTANT GLIOBLASTOMA MOUSE MODEL

Glioblastoma with acquired resistance to bevacizumab therapy overexpresses c-MET which mediates tumor growth, EMT, invasion, and metastasis. We evaluated the expression level of total and phosphorylated c-MET (p-c-MET) and the inhibitory activity of altiratinib (DCC-2701), a novel c-MET/TIE2/VEGFR i...

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Hauptverfasser: Piao, Yuji, Smith, Bryan, Thomas, Craig, Holmes, Lindsay, Henry, Verlene, Flynn, Daniel L., de Groot, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217864/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou238.25
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