Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype

Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis. Inhibiting the VEGF–VEGF receptor (R) signal transduction pathway in glioblastoma has recently been shown to delay progression, but the relative benefit and mechanisms of response and failure of anti-VEGF therapy and...

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Detalhes bibliográficos
Main Authors: Piao, Yuji, Liang, Ji, Holmes, Lindsay, Zurita, Amado J., Henry, Verlene, Heymach, John V., de Groot, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480262/
https://ncbi.nlm.nih.gov/pubmed/22965162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos158
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