Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype

Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis. Inhibiting the VEGF–VEGF receptor (R) signal transduction pathway in glioblastoma has recently been shown to delay progression, but the relative benefit and mechanisms of response and failure of anti-VEGF therapy and...

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Hlavní autoři: Piao, Yuji, Liang, Ji, Holmes, Lindsay, Zurita, Amado J., Henry, Verlene, Heymach, John V., de Groot, John F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480262/
https://ncbi.nlm.nih.gov/pubmed/22965162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos158
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