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AI-25 THE NOVEL c-MET INHIBITOR ALTIRATINIB (DCC-2701) INHIBITS TUMOR GROWTH AND INVASION IN A BEVACIZUMAB RESISTANT GLIOBLASTOMA MOUSE MODEL
Glioblastoma with acquired resistance to bevacizumab therapy overexpresses c-MET which mediates tumor growth, EMT, invasion, and metastasis. We evaluated the expression level of total and phosphorylated c-MET (p-c-MET) and the inhibitory activity of altiratinib (DCC-2701), a novel c-MET/TIE2/VEGFR i...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4217864/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou238.25 |
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