Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner

Even though the role of the tyrosine phosphatase Pten as a tumor suppressor gene has been well established in thyroid cancer, its role during thyroid development is still elusive. We therefore targeted Pten deletion in the thyroid epithelium by crossing Pten(flox/flox) with a newly developed Nkx2.1-...

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Detalhes bibliográficos
Main Authors: Tiozzo, Caterina, Danopoulos, Soula, Lavarreda-Pearce, Maria, Baptista, Sheryl, Varimezova, Radka, Al Alam, Denise, Warburton, David, Virender, Rehan, De Langhe, Stijn, Di Cristofano, Antonio, Bellusci, Saverio, Minoo, Parviz
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217534/
https://ncbi.nlm.nih.gov/pubmed/22167068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-10-0327
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