Deletion of Pten Expands Lung Epithelial Progenitor Pools and Confers Resistance to Airway Injury

Rationale: Pten is a tumor-suppressor gene involved in stem cell homeostasis and tumorigenesis. In mouse, Pten expression is ubiquitous and begins as early as 7 days of gestation. Pten(−/−) mouse embryos die early during gestation indicating a critical role for Pten in embryonic development. Objecti...

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Detalhes bibliográficos
Main Authors: Tiozzo, Caterina, De Langhe, Stijn, Yu, Mingke, Londhe, Vedang A., Carraro, Gianni, Li, Min, Li, Changgong, Xing, Yiming, Anderson, Stewart, Borok, Zea, Bellusci, Saverio, Minoo, Parviz
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2009
Assuntos:
A. Airway Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778148/
https://ncbi.nlm.nih.gov/pubmed/19574443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200901-0100OC
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