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Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization
Thymosin-β4 (Tβ4) and profilin are the two major sequestering proteins that maintain the pool of monomeric actin (G-actin) within cells of higher eukaryotes. Tβ4 prevents G-actin from joining a filament, whereas profilin:actin only supports barbed-end elongation. Here, we report two Tβ4:actin struct...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4217450/ https://ncbi.nlm.nih.gov/pubmed/25313062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412271111 |
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