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Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy

Inflammasomes are intracellular sensors that couple detection of pathogens and cellular stress to activation of Caspase-1, and consequent IL-1β and IL-18 maturation and pyroptotic cell death. Here, we show that the absent in melanoma 2 (AIM2) and nucleotide-binding oligomerization domain-like recept...

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Detalhes bibliográficos
Main Authors: Yu, Jiujiu, Nagasu, Hajime, Murakami, Tomohiko, Hoang, Hai, Broderick, Lori, Hoffman, Hal M., Horng, Tiffany
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217429/
https://ncbi.nlm.nih.gov/pubmed/25313054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414859111
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