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Up-and-down designs for phase I clinical trials
Various up-and-down designs have been proposed to improve the operating characteristics of the traditional “3+3” design, but they have been of limited use in practice. A major impediment to the adoption of the improved up-and-down designs is a lack of general guidance and a comprehensive assessment...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4217164/ https://ncbi.nlm.nih.gov/pubmed/23856381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2013.07.002 |
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