Intestinal epithelial expression of TNFAIP3 results in microbial invasion of the inner mucus layer and induces colitis in IL-10-deficient mice

Tumor necrosis factor-induced protein 3 (TNFAIP3; also known as A20) negatively regulates NF-κB and MAPK signals to control inflammatory responses. TNFAIP3 also protects against TNF-induced cell death. Intestinal epithelial cell (IEC) expression of TNFAIP3 improves barrier function and tight junctio...

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Auteurs principaux: Murphy, Stephen F., Rhee, Lesley, Grimm, Wesley A., Weber, Christopher R., Messer, Jeannette S., Lodolce, James P., Chang, Jonathan E., Bartulis, Sarah J., Nero, Thomas, Kukla, Renata A., MacDougall, Gordon, Binghay, Charles, Kolodziej, Lauren E., Boone, David L.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2014
Sujets:
Inflammation/Immunity/Mediators
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216993/
https://ncbi.nlm.nih.gov/pubmed/25234043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00020.2014
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