TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data

The evolution of cancer genomes within a single tumor creates mixed cell populations with divergent somatic mutational landscapes. Inference of tumor subpopulations has been disproportionately focused on the assessment of somatic point mutations, whereas computational methods targeting evolutionary...

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Detalhes bibliográficos
Main Authors: Ha, Gavin, Roth, Andrew, Khattra, Jaswinder, Ho, Julie, Yap, Damian, Prentice, Leah M., Melnyk, Nataliya, McPherson, Andrew, Bashashati, Ali, Laks, Emma, Biele, Justina, Ding, Jiarui, Le, Alan, Rosner, Jamie, Shumansky, Karey, Marra, Marco A., Gilks, C. Blake, Huntsman, David G., McAlpine, Jessica N., Aparicio, Samuel, Shah, Sohrab P.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216928/
https://ncbi.nlm.nih.gov/pubmed/25060187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.180281.114
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