Molecular Profiling of Patient-Matched Brain and Extracranial Melanoma Metastases Implicates the PI3K Pathway as a Therapeutic Target

PURPOSE: An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences be...

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Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Chen, Guo, Chakravarti, Nitin, Aardalen, Kimberly, Lazar, Alexander J., Tetzlaff, Michael T., Wubbenhorst, Bradley, Kim, Sang-Bae, Kopetz, Scott, Ledoux, Alicia A., Gopal, Y.N. Vashisht, Pereira, Cristiano Goncalves, Deng, Wanleng, Lee, Ju-Seog, Nathanson, Katherine L., Aldape, Kenneth D., Prieto, Victor G., Stuart, Darrin, Davies, Michael A.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216765/
https://ncbi.nlm.nih.gov/pubmed/24803579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3003
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