Molecular Profiling of Patient-Matched Brain and Extracranial Melanoma Metastases Implicates the PI3K Pathway as a Therapeutic Target

PURPOSE: An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences be...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Chen, Guo, Chakravarti, Nitin, Aardalen, Kimberly, Lazar, Alexander J., Tetzlaff, Michael T., Wubbenhorst, Bradley, Kim, Sang-Bae, Kopetz, Scott, Ledoux, Alicia A., Gopal, Y.N. Vashisht, Pereira, Cristiano Goncalves, Deng, Wanleng, Lee, Ju-Seog, Nathanson, Katherine L., Aldape, Kenneth D., Prieto, Victor G., Stuart, Darrin, Davies, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216765/
https://ncbi.nlm.nih.gov/pubmed/24803579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3003
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