Molecular Profiling of Patient-Matched Brain and Extracranial Melanoma Metastases Implicates the PI3K Pathway as a Therapeutic Target

PURPOSE: An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences be...

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Опубликовано в: :Clin Cancer Res
Главные авторы: Chen, Guo, Chakravarti, Nitin, Aardalen, Kimberly, Lazar, Alexander J., Tetzlaff, Michael T., Wubbenhorst, Bradley, Kim, Sang-Bae, Kopetz, Scott, Ledoux, Alicia A., Gopal, Y.N. Vashisht, Pereira, Cristiano Goncalves, Deng, Wanleng, Lee, Ju-Seog, Nathanson, Katherine L., Aldape, Kenneth D., Prieto, Victor G., Stuart, Darrin, Davies, Michael A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216765/
https://ncbi.nlm.nih.gov/pubmed/24803579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3003
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