Molecular Profiling of Patient-Matched Brain and Extracranial Melanoma Metastases Implicates the PI3K Pathway as a Therapeutic Target

PURPOSE: An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences be...

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Publicat a:Clin Cancer Res
Autors principals: Chen, Guo, Chakravarti, Nitin, Aardalen, Kimberly, Lazar, Alexander J., Tetzlaff, Michael T., Wubbenhorst, Bradley, Kim, Sang-Bae, Kopetz, Scott, Ledoux, Alicia A., Gopal, Y.N. Vashisht, Pereira, Cristiano Goncalves, Deng, Wanleng, Lee, Ju-Seog, Nathanson, Katherine L., Aldape, Kenneth D., Prieto, Victor G., Stuart, Darrin, Davies, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216765/
https://ncbi.nlm.nih.gov/pubmed/24803579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3003
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