Antisense-Mediated Inhibition of Human Immunodeficiency Virus (HIV) Replication by Use of an HIV Type 1-Based Vector Results in Severely Attenuated Mutants Incapable of Developing Resistance

We have constructed a human immunodeficiency virus type 1 (HIV-1)-based lentiviral vector expressing a 937-base antisense sequence against the HIV-1 envelope gene. Transduction of CD4(+) T lymphocytes with this vector results in expression of the therapeutic antisense sequence and subsequent inhibit...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Lu, Xiaobin, Yu, Qiao, Binder, Gwendolyn K., Chen, Ziping, Slepushkina, Tatiana, Rossi, John, Dropulic, Boro
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2004
Assuntos:
Gene Therapy
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC421644/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15194784/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.13.7079-7088.2004
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares