Antisense-Mediated Inhibition of Human Immunodeficiency Virus (HIV) Replication by Use of an HIV Type 1-Based Vector Results in Severely Attenuated Mutants Incapable of Developing Resistance

We have constructed a human immunodeficiency virus type 1 (HIV-1)-based lentiviral vector expressing a 937-base antisense sequence against the HIV-1 envelope gene. Transduction of CD4(+) T lymphocytes with this vector results in expression of the therapeutic antisense sequence and subsequent inhibit...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Lu, Xiaobin, Yu, Qiao, Binder, Gwendolyn K., Chen, Ziping, Slepushkina, Tatiana, Rossi, John, Dropulic, Boro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC421644/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15194784/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.13.7079-7088.2004
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