Antisense-Mediated Inhibition of Human Immunodeficiency Virus (HIV) Replication by Use of an HIV Type 1-Based Vector Results in Severely Attenuated Mutants Incapable of Developing Resistance

We have constructed a human immunodeficiency virus type 1 (HIV-1)-based lentiviral vector expressing a 937-base antisense sequence against the HIV-1 envelope gene. Transduction of CD4(+) T lymphocytes with this vector results in expression of the therapeutic antisense sequence and subsequent inhibit...

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Autori principali: Lu, Xiaobin, Yu, Qiao, Binder, Gwendolyn K., Chen, Ziping, Slepushkina, Tatiana, Rossi, John, Dropulic, Boro
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Gene Therapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC421644/
https://ncbi.nlm.nih.gov/pubmed/15194784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.13.7079-7088.2004
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