Hydroxylated Derivatives of NPC1161: Theoretical Insights into Their Potential Toxicity and the Feasibility and Regioselectivity of Their Formation

[Image: see text] For antimalarial 8-aminoquinoline (8-AQ) drugs, the ionization potential (energy required to remove an electron) of their putative metabolites has been proposed to be correlated in part to their hemotoxicity potential. NPC1161 is a developmental candidate as an 8-AQ antimalarial dr...

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Hauptverfasser: Ding, Yuanqing, Liu, Haining, Nanayakkara, N. P. Dhammika, Khan, Ikhlas A., Tekwani, Babu L., Walker, Larry A., Doerksen, Robert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216223/
https://ncbi.nlm.nih.gov/pubmed/24956138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp502612t
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