Enantioselective Interactions of Anti-Infective 8-Aminoquinoline Therapeutics with Human Monoamine Oxidases A and B †

8-Aminoquinolines (8-AQs) are an important class of anti-infective therapeutics. The monoamine oxidases (MAOs) play a key role in metabolism of 8-AQs. A major role for MAO-A in metabolism of primaquine (PQ), the prototypical 8-AQ antimalarial, has been demonstrated. These investigations were further...

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Veröffentlicht in:Pharmaceuticals (Basel)
Hauptverfasser: Chaurasiya, Narayan D., Liu, Haining, Doerksen, Robert J., Nanayakkara, N. P. Dhammika, Walker, Larry A., Tekwani, Babu L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8146505/
https://ncbi.nlm.nih.gov/pubmed/33922294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14050398
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