Antileishmanial Activity of a Series of N(2),N(4)-Disubstituted Quinazoline-2,4-diamines

[Image: see text] A series of N(2),N(4)-disubstituted quinazoline-2,4-diamines has been synthesized and tested against Leishmania donovani and L. amazonensis intracellular amastigotes. A structure–activity and structure–property relationship study was conducted in part using the Topliss operational...

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Hauptverfasser: Van Horn, Kurt S., Zhu, Xiaohua, Pandharkar, Trupti, Yang, Sihyung, Vesely, Brian, Vanaerschot, Manu, Dujardin, Jean-Claude, Rijal, Suman, Kyle, Dennis E., Wang, Michael Zhuo, Werbovetz, Karl A., Manetsch, Roman
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216219/
https://ncbi.nlm.nih.gov/pubmed/24874647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5000408
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