Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes

[Image: see text] It is becoming increasingly clear that site-specific conjugation offers significant advantages over conventional conjugation chemistries used to make antibody–drug conjugates (ADCs). Site-specific payload placement allows for control over both the drug-to-antibody ratio (DAR) and t...

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Publicado en:Bioconjug Chem
Autores principales: Drake, Penelope M., Albers, Aaron E., Baker, Jeanne, Banas, Stefanie, Barfield, Robyn M., Bhat, Abhijit S., de Hart, Gregory W., Garofalo, Albert W., Holder, Patrick, Jones, Lesley C., Kudirka, Romas, McFarland, Jesse, Zmolek, Wes, Rabuka, David
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215875/
https://ncbi.nlm.nih.gov/pubmed/24924618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc500189z
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