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Site-Specific Tandem Knoevenagel Condensation–Michael Addition To Generate Antibody–Drug Conjugates

[Image: see text] Expanded ligation techniques are sorely needed to generate unique linkages for the growing field of functionally enhanced proteins. To address this need, we present a unique chemical ligation that involves the double addition of a pyrazolone moiety with an aldehyde-labeled protein....

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Foilsithe in:ACS Med Chem Lett
Main Authors: Kudirka, Romas A., Barfield, Robyn M., McFarland, Jesse M., Drake, Penelope M., Carlson, Adam, Bañas, Stefanie, Zmolek, Wes, Garofalo, Albert W., Rabuka, David
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2016
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108035/
https://ncbi.nlm.nih.gov/pubmed/27882197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00253
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