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Direct inhibition of hypothalamic proopiomelanocortin neurons by dynorphin A is mediated by the μ-opioid receptor

It has recently been shown that dynorphin A (Dyn A), an endogenous agonist of the κ-opioid receptor (KOR), directly inhibits proopiomelanocortin (POMC) neurons in the hypothalamus through activation of G-protein-coupled inwardly rectifying K(+) channels (GIRKs). This effect has been proposed to be m...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pennock, Reagan L, Hentges, Shane T
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Science Inc 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215775/
https://ncbi.nlm.nih.gov/pubmed/25085890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.275339
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