Differential Desensitization Observed at Multiple Effectors of Somatic μ-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity

Activation of somatic μ-opioid receptors (MORs) in hypothalamic proopiomelanocortin (POMC) neurons leads to the activation of G-protein-coupled inward rectifier potassium (GIRK) channels and hyperpolarization, but in response to continued signaling MORs undergo acute desensitization resulting in rob...

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Vydáno v:J Neurosci
Hlavní autoři: Fox, Philip D., Hentges, Shane T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588460/
https://ncbi.nlm.nih.gov/pubmed/28821664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1030-17.2017
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