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Desensitization of Functional µ-Opioid Receptors Increases Agonist Off-Rate
Desensitization of µ-opioid receptors (MORs) develops over 5–15 minutes after the application of some, but not all, opioid agonists and lasts for tens of minutes after agonist removal. The decrease in function is receptor selective (homologous) and could result from 1) a reduction in receptor number...
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| Natura: | Artigo |
| Lingua: | Inglês |
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The American Society for Pharmacology and Experimental Therapeutics
2014
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4054003/ https://ncbi.nlm.nih.gov/pubmed/24748657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.092098 |
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