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Agonist Binding and Desensitization of the μ-Opioid Receptor Is Modulated by Phosphorylation of the C-Terminal Tail Domain

Sustained activation of G protein–coupled receptors can lead to a rapid decline in signaling through acute receptor desensitization. In the case of the μ-opioid receptor (MOPr), this desensitization may play a role in the development of analgesic tolerance. It is understood that phosphorylation of M...

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Publicat a:Mol Pharmacol
Autors principals: Birdsong, William T., Arttamangkul, Seksiri, Bunzow, James R., Williams, John T.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576685/
https://ncbi.nlm.nih.gov/pubmed/25934731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.097527
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