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Separation of Acute Desensitization and Long-Term Tolerance of µ-Opioid Receptors Is Determined by the Degree of C-Terminal Phosphorylation

Phosphorylation of sites on the C terminus of the μ-opioid receptor (MOR) results in the induction of acute desensitization that is thought to be a precursor for the development of long-term tolerance. Alanine mutations of all 11 phosphorylation sites on the C terminus of MORs almost completely abol...

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Bibliografiske detaljer
Udgivet i:Mol Pharmacol
Main Authors: Arttamangkul, Seksiri, Leff, Emily R., Koita, Omar, Birdsong, William T., Williams, John T.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750191/
https://ncbi.nlm.nih.gov/pubmed/31383769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.117358
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