A Kinase Inhibitor Screen Reveals Protein Kinase C-dependent Endocytic Recycling of ErbB2 in Breast Cancer Cells

ErbB2 overexpression drives oncogenesis in 20–30% cases of breast cancer. Oncogenic potential of ErbB2 is linked to inefficient endocytic traffic into lysosomes and preferential recycling. However, regulation of ErbB2 recycling is incompletely understood. We used a high-content immunofluorescence im...

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Autors principals: Bailey, Tameka A., Luan, Haitao, Tom, Eric, Bielecki, Timothy Alan, Mohapatra, Bhopal, Ahmad, Gulzar, George, Manju, Kelly, David L., Natarajan, Amarnath, Raja, Srikumar M., Band, Vimla, Band, Hamid
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215227/
https://ncbi.nlm.nih.gov/pubmed/25225290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.608992
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