Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene

The polycyclic aromatic hydrocarbon (PAH) benzo(a)pyrene (BP) is thought to bind covalently to DNA, through metabolism by cytochrome P450 1A1 (CYP1A1) and CYP1B1, and other enzymes, to form r7, t8, t9-trihydroxy-c-10-(N (2)-deoxyguanosyl)-7,8,9,10-tetrahydro-benzo[a]-pyrene (BPdG). Evaluation of RNA...

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Publicado en:Mutagenesis
Main Authors: Divi, Rao L., Einem Lindeman, Tracey L., Shockley, Marie E., Keshava, Channa, Weston, Ainsley, Poirier, Miriam C.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
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Original Manuscript
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215068/
https://ncbi.nlm.nih.gov/pubmed/25245543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/geu049
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