CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin

Benzo[a]pyrene (BP) is a potent pro-carcinogen and ubiquitous environmental pollutant. Here, we examined the induction and modulation of CYP1A1 and CYP1B1 and 10-(deoxyguanosin-N(2)-yl)-7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPdG) adduct formation in DNA from 20 primary normal human mam...

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Main Authors: John, Kaarthik, Divi, Rao L., Keshava, Channa, Orozco, Christine C., Schockley, Marie E., Richardson, Diana L., Poirier, Miriam C., Nath, Joginder, Weston, Ainsley
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475201/
https://ncbi.nlm.nih.gov/pubmed/20163913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2009.12.008
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