Chlorophyllin significantly reduces benzo[a]pyrene [BP]-DNA adduct formation and alters Cytochrome P450 1A1 and 1B1 expression and EROD activity in normal human mammary epithelial cells (NHMECs)

We hypothesized that chlorophyllin (CHLN) would reduce BP-DNA adduct levels. Using NHMECs exposed to 4 μM BP for 24 hr in the presence or absence of 5 μM CHLN, we measured BP-DNA adducts by chemiluminescence immunoassay (CIA). The protocol included the following experimental groups: BP alone, BP giv...

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Detalhes bibliográficos
Main Authors: Keshava, Channa, Divi, Rao L., Einem, Tracey L., Richardson, Diana L., Leonard, Sarah L., Keshava, Nagalakshmi, Poirier, Miriam C., Weston, Ainsley
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637934/
https://ncbi.nlm.nih.gov/pubmed/19152381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.20449
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