Blockade of the Programmed Death-1 Pathway Restores Sarcoidosis CD4(+) T-Cell Proliferative Capacity

Rationale: Effective therapeutic interventions for chronic, idiopathic lung diseases remain elusive. Normalized T-cell function is an important contributor to spontaneous resolution of pulmonary sarcoidosis. Up-regulation of inhibitor receptors, such as programmed death-1 (PD-1) and its ligand, PD-L...

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Main Authors: Braun, Nicole A., Celada, Lindsay J., Herazo-Maya, Jose D., Abraham, Susamma, Shaginurova, Guzel, Sevin, Carla M., Grutters, Jan, Culver, Daniel A., Dworski, Ryszard, Sheller, James, Massion, Pierre P., Polosukhin, Vasiliy V., Johnson, Joyce E., Kaminski, Naftali, Wilkes, David S., Oswald-Richter, Kyra A., Drake, Wonder P.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2014
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214083/
https://ncbi.nlm.nih.gov/pubmed/25073001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201401-0188OC
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