Local and Systemic CD4(+) T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis

Investigation of the Th1 immune response in sarcoidosis CD4(+) T cells has revealed reduced proliferative capacity and cytokine expression upon TCR stimulation. In other disease models, such cellular dysfunction has been associated with a step-wise, progressive loss of T cell function that results f...

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Veröffentlicht in:J Immunol Res
Hauptverfasser: Hawkins, Charlene, Shaginurova, Guzel, Shelton, D. Auriel, Herazo-Maya, Jose D., Oswald-Richter, Kyra A., Rotsinger, Joseph E., Young, Anjuli, Celada, Lindsay J., Kaminski, Naftali, Sevin, Carla, Drake, Wonder P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695030/
https://ncbi.nlm.nih.gov/pubmed/29234685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/3642832
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