Blockade of the Programmed Death-1 Pathway Restores Sarcoidosis CD4(+) T-Cell Proliferative Capacity

Rationale: Effective therapeutic interventions for chronic, idiopathic lung diseases remain elusive. Normalized T-cell function is an important contributor to spontaneous resolution of pulmonary sarcoidosis. Up-regulation of inhibitor receptors, such as programmed death-1 (PD-1) and its ligand, PD-L...

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Detalhes bibliográficos
Main Authors: Braun, Nicole A., Celada, Lindsay J., Herazo-Maya, Jose D., Abraham, Susamma, Shaginurova, Guzel, Sevin, Carla M., Grutters, Jan, Culver, Daniel A., Dworski, Ryszard, Sheller, James, Massion, Pierre P., Polosukhin, Vasiliy V., Johnson, Joyce E., Kaminski, Naftali, Wilkes, David S., Oswald-Richter, Kyra A., Drake, Wonder P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214083/
https://ncbi.nlm.nih.gov/pubmed/25073001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201401-0188OC
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