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Reversal of global CD4+ subset dysfunction is associated with spontaneous clinical resolution of pulmonary sarcoidosis

Sarcoidosis pathogenesis is characterized by peripheral anergy and an exaggerated, pulmonary CD4+ Th1 response. In this study, we demonstrate that CD4+ anergic responses to polyclonal TCR stimulation are present peripherally and within the lungs of sarcoid patients. Consistent with prior observation...

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Detalhes bibliográficos
Main Authors: Oswald-Richter, Kyra A., Richmond, Bradley W., Braun, Nicole A., Isom, Joan, Abraham, Susamma, Taylor, Thyneice R., Drake, John M., Culver, Daniel A., Wilkes, David S., Drake, Wonder P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660530/
https://ncbi.nlm.nih.gov/pubmed/23630356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202891
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