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Domain and Interdomain Energetics Underlying Gating in Shaker-Type K(V) Channels

To understand gating events with a time-base many orders-of-magnitude slower than that of atomic motion in voltage-gated ion channels such as the Shaker-type K(V) channels, a multiscale physical model is constructed from the experimentally well-characterized voltage-sensor (VS) domains coupled to a...

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Détails bibliographiques
Auteurs principaux: Peyser, Alexander, Gillespie, Dirk, Roth, Roland, Nonner, Wolfgang
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213693/
https://ncbi.nlm.nih.gov/pubmed/25418165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.08.015
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