Resistance to Selumetinib (AZD6244) in Colorectal Cancer Cell Lines is Mediated by p70S6K and RPS6 Activation()

Selumetinib (AZD6244, ARRY-142886) is a MEK1/2 inhibitor that has gained interest as an anti-tumour agent. We have determined the degree of sensitivity/resistance to Selumetinib in a panel of colorectal cancer cell lines using cell proliferation and soft agar assays. Sensitive cell lines underwent G...

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Autori principali: Grasso, Silvina, Tristante, Elena, Saceda, Miguel, Carbonell, Pablo, Mayor-López, Leticia, Carballo-Santana, Mar, Carrasco-García, Estefanía, Rocamora-Reverte, Lourdes, García-Morales, Pilar, Carballo, Fernando, Ferragut, José A., Martínez-Lacaci, Isabel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4212257/
https://ncbi.nlm.nih.gov/pubmed/25379021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.08.011
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