Development, Characterization, and Reversal of Acquired Resistance to the MEK1 Inhibitor Selumetinib (AZD6244) in an In Vivo Model of Childhood Astrocytoma

PURPOSE: The BT-40 low-grade childhood astrocytoma xenograft model expresses mutated BRAF(V600E) and is highly sensitive to the MEK inhibitor selumetinib (AZD6244). In this study we developed and characterized selumetinib resistance and explored approaches to circumventing the mechanism(s) of acquir...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Bid, Hemant K., Kibler, Aaron, Phelps, Doris A., Manap, Sagymbek, Xiao, Linlin, Lin, Jiayuh, Capper, David, Oswald, Duane, Geier, Brian, DeWire, Mariko, Smith, Paul D., Kurmasheva, Raushan T., Mo, Xiaokui, Fernandez, Soledad, Houghton, Peter J.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086218/
https://ncbi.nlm.nih.gov/pubmed/24132923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0842
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars