Development, Characterization, and Reversal of Acquired Resistance to the MEK1 Inhibitor Selumetinib (AZD6244) in an In Vivo Model of Childhood Astrocytoma

PURPOSE: The BT-40 low-grade childhood astrocytoma xenograft model expresses mutated BRAF(V600E) and is highly sensitive to the MEK inhibitor selumetinib (AZD6244). In this study we developed and characterized selumetinib resistance and explored approaches to circumventing the mechanism(s) of acquir...

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Main Authors: Bid, Hemant K., Kibler, Aaron, Phelps, Doris A., Manap, Sagymbek, Xiao, Linlin, Lin, Jiayuh, Capper, David, Oswald, Duane, Geier, Brian, DeWire, Mariko, Smith, Paul D., Kurmasheva, Raushan T., Mo, Xiaokui, Fernandez, Soledad, Houghton, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086218/
https://ncbi.nlm.nih.gov/pubmed/24132923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0842
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